含有不同宏观营养素的地中海饮食对非酒精性脂肪肝疾病的有效性
Vahibe Uluçay Kestane1,2, Murat Baş3
1Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Nutrients
|August 29, 2024
概括
地中海饮食,在典型的,低碳水化合物或低脂肪形式,改善了肥胖和非酒精性脂肪性肝病 (NAFLD) 患者的肝脏健康标志物. 不同的饮食成分对肝酶和脂肪肝指数 (FLI) 有不同的影响.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 越来越令人担忧,特别是在肥胖和胰岛素抵抗的人群中.
- 饮食干预对于管理NAFLD及其相关代谢并发症至关重要.
- 地中海饮食 (MD) 已被公认为具有健康益处,但其特定变体对NAFLD的影响需要进一步研究.
研究的目的:
- 为了比较典型的地中海饮食 (TMD),低碳水化合物地中海饮食 (LCMD) 和低脂肪地中海饮食 (LFMD) 对肥胖,胰岛素抵抗和NAFLD患者的影响.
- 评估这些饮食干预措施对生物化学发现,脂肪肝指数 (FLI),纤维化-4指数 (FIB-4),人体测量和身体组成的影响.
- 为了确定特定营养摄入量的变化和肝脏健康标志物的改善之间的相关性.
主要方法:
- 一项随机对照试验,涉及63名参与者,患有肥胖,胰岛素抵抗和通过超声波诊断的NAFLD.
- 参与者被分配到三个8周的能量限制饮食之一:TMD,LCMD或LFMD.
- 使用每周面对面的面试和食物消费记录来监测饮食遵守和摄入量.
主要成果:
- 在糖糖,总脂肪,单不和脂肪酸,多不和脂肪酸,油酸,纤维和胆固醇摄入量变化与肝酶和FLI的改善之间观察到显著的相关性 (p < 0.05).
- 地中海饮食的所有三种变化都对生物化学参数和FLI产生了积极影响.
- 具体的营养摄入量差异与肝脏健康的改善相关,这表明每个饮食模式都有不同的作用机制.
结论:
- 地中海饮食,无论其宏观营养素成分 (典型的,低碳水化合物或低脂肪) 是什么,都可能对NAFLD患者的生物化学参数和FLI产生积极影响.
- 在地中海地区,不同的饮食模式可以通过不同的营养途径发挥有益作用.
- 这些发现支持地中海饮食的适应性,作为一种治疗策略,用于风险人群中管理NAFLD.
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