患有基尿症的成人的营养状况和摄入量
Eva Venegas1, Simone Langeveld2, Kirsten Ahring3
1Endocrinology and Nutrition Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
Nutrients
|August 29, 2024
概括
服用蛋白替代品 (PSs) 的成年人患有基尿症 (PKU) 显示出足够的微量营养素状态,但较低的和泛. 尽管维生素和矿物质摄入量较高,但在某些领域的认知功能受损.
科学领域:
- 生物化学 生物化学
- 人类营养人类营养
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 基尿症 (PKU) 管理依赖于限制氨酸的饮食和蛋白质替代品 (PSs).
- 坚持饮食管理是成年时面临的挑战.
- 关于早期和持续治疗PKU (ETAwPKU) 的成年人营养状况的数据有限.
研究的目的:
- 为了将ETAwPKU的血液营养状况,饮食摄入量和认知健康状况与年龄和性别匹配的对照进行比较.
- 评估PSs在满足ETAwPKU.KU的营养需求中的作用.
主要方法:
- 横截面研究比较34个ETAwPKU与34个对照.
- 对血液营养物质度的分析 (DHA,矿物质,维生素,氨基酸).
- 用问卷评估自我报告的饮食摄入量和认知健康状况.
主要成果:
- 与对照组相比,ETAwPKU的血和乌比奎农度较低.
- 在ETAwPKU中,维生素D,B12,B6和叶酸水平较高,而α-托哥菲罗尔水平较低.
- ETAwPKU表现出改变的氨基酸概况,其中12个AAs的水平较低,氨酸和甘氨酸的水平较高.
- 尽管大多数微量营养素的饮食摄入量较高,但ETAwPKU在四个子尺度中的三个中在认知健康方面得分较低.
结论:
- ETAwPKU的整体血液DHA和微量营养素状态是充足的,除了.
- 蛋白质替代品对于ETAwPKU来说至关重要,以满足蛋白质,DHA和微量营养素的建议摄入量.
- 需要进一步的研究,以了解ETAwPKU中氨基酸状况变化的临床影响.
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