饮食中的异黄摄入量和胃癌
Arianna Natale1, Federica Fiori2, Maria Parpinel2
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, 20133 Milan, Italy.
Nutrients
|August 29, 2024
概括
饮食中的异黄可能会降低胃癌的风险. 这项研究发现,摄入较高的异黄,如大吉素,与患胃癌 (GC) 的可能性较低有关.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 饮食中的异黄是一种具有潜在健康益处的植物化合物.
- 以前的研究表明,异黄与胃癌 (GC) 风险降低之间可能存在联系,但证据有限.
- 胃癌仍然是一个重大的全球健康问题.
研究的目的:
- 调查饮食中异黄摄入量与患胃癌的风险之间的关联.
- 量化GC风险的几率比率 (OR) 和置信区间 (CI) 在不同水平的异黄素消费中.
主要方法:
- 对230例胃癌病例和547例对照进行了病例对照研究.
- 通过验证的食物频率问卷 (FFQ) 评估了饮食摄入量.
- 使用专业数据库计算异黄摄入量,并使用后勤回归模型分析数据,调整混因素.
主要成果:
- 较高的戴兹摄入量与降低的GC风险有关 (OR = 0.65,95% CI = 0.44-0.97,p趋势 = 0.04).
- 总的异黄摄入量也显示出与GC风险的显著反向关联 (OR = 0.66,95% CI = 0.45-0.99,p趋势 = 0.05).
- 对于热尼斯坦,没有发现显著的相关性 (OR = 0.75,95% CI = 0.54-1.11,p趋势 = 0.15).
结论:
- 饮食中含有的异黄,特别是大吉素,似乎对抗胃癌具有保护作用.
- 这些发现有助于了解饮食在预防胃癌中的作用.
- 进一步的研究可能会阐明这种关联背后的具体机制.
相关概念视频
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
328
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
01:27Gastritis-I: Introduction and Types
312
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
312
01:50What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:34Inhibition of Cdk Activity
4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K