发酵大豆 (FSB) 补充剂对胃食道逆流性疾病 (GERD) 的影响
Eugenie Sin Sing Tan1, Rahela Zaman1, Muhammad Akbar Memon2
1Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur 56000, Malaysia.
Nutrients
|August 29, 2024
概括
发酵大豆 (FSB) 补充剂显著降低了胃食道逆流症 (GERD) 的症状和炎症. 这项研究突出了FSB的重点.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种常见的慢性疾病,影响一般医疗实践.
- 关于发酵大豆 (FSB) 用于治疗GERD的研究正在出现,关于最佳剂量和持续时间的数据有限.
- 现有的研究往往缺乏严格性来区分安慰剂效应和真正的益处.
研究的目的:
- 调查发酵大豆 (FSB) 补充剂在管理GERD症状中的有效性.
- 通过测量关键炎症标志物来评估FSB的抗炎作用.
- 评估FSB对GERD患者生活质量的影响.
主要方法:
- 一项为期12周的研究涉及110名参与者 (NCT06524271),每天接受1g的FSB.
- 使用反流性疾病问卷 (RDQ) 评估了GERD症状.
- 测量了炎症标志物 (IL-4,IL-6,IL-8) 和反流和消化不良 (QOLRAD) 的生活质量得分.
主要成果:
- 补充FSB显著降低了胃烧和吐症状 (p <0.05).
- 观察到炎症标志物 (IL-4,IL-6,IL-8) 的显著降低,表明抗炎作用.
- 科拉德评分显著改善,特别是在活力,情绪困扰和身体/社会功能方面 (p < 0.05).
结论:
- 补充FSB在缓解GERD症状方面显示出显著的好处.
- FSB表现出与GERD管理相关的显著抗炎性质.
- FSB改善了患有GERD的患者的整体生活质量,支持其作为辅助疗法的使用.
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