骨矿物质密度在一生中发生变化的全面分析:来自国家调查的见解
Tao Li1, Guimin Huang1, Dongqing Hou1
1Child Health Big Data Research Center, Capital Institute of Pediatrics, Beijing 100020, China.
Nutrients
|August 29, 2024
概括
骨矿物质密度 (BMD) 在女性中较早达到峰值,观察到种族差异. 非西班牙裔黑人表现出更高的BMD,而男性更早地达到平原. 这项研究为骨健康策略提供了信息.
科学领域:
- 骨质疏松症和骨健康研究.
- 人类生理学和衰老研究.
背景情况:
- 我们对骨矿物质密度 (BMD) 在生命周期中的变化了解有限.
- 需要关于从童年到老年时代的骨损伤模式的全面数据.
研究的目的:
- 为了研究整个生命阶段的BMD变化:童年,青春期,成年期和老年期.
- 为了确定峰值骨矿物质密度 (PBMD) 的关键时间.
- 探索BMD模式中的种族变异.
主要方法:
- 从NHANES (1999-2018) 分析了46381名 (LSBMD) 和20944名 (FNBMD) 参与者 (年龄在8-85岁之间).
- 通过双能X射线吸收计测量 BMD 的测量.
- 用于光滑百分位曲线构造的通用添加模型.
主要成果:
- 雌性比雄性更早达到腰椎BMD (LSBMD) 的峰值,第二个峰值在36-37岁左右.
- 男性的LSBMD高原在30岁左右. 一般来说,女性的LSBMD比男性高,直到50岁,除非西班牙裔黑人外.
- 非西班牙裔黑人表现出最高的BMD;墨西哥裔美国人通常是最低的. 股骨部 BMD (FNBMD) 在 LSBMD 之前达到峰值,男性的 FNBMD 较高.
结论:
- 提供了关于骨质量变化和峰值骨质量的寿命视角.
- 突出了BMD的种族差异,非西班牙裔黑人显示出更高的水平.
- 提供了针对不同人群的骨健康干预措施的见解.
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