与阿片类药物相关的滥用,滥用和药物错误的不良事件 - 一个系统性审查
Moa Gustafsson1, Vítor Silva2, Carolina Valeiro3
1Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden.
Pharmaceuticals (Basel, Switzerland)
|August 29, 2024
概括
本综述确定了阿片类药物滥用,滥用和药物错误的不良事件. 芬太尼,吗啡和 oxycodone 经常与可预防的伤害有关,需要采取更好的安全措施.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 临床药房 临床药房
背景情况:
- 阿片类药物是强大的止痛药,对于疼痛管理至关重要.
- 了解非治疗性阿片类药物使用 (滥用,滥用,错误) 对安全性和有效性至关重要.
- 由这些问题引起的不良事件需要进行系统的调查.
研究的目的:
- 系统地审查和识别与阿片类药物滥用,滥用和药物错误相关的已知不良事件.
- 综合当前关于非标准阿片类药物使用的危害范围和性质的知识.
主要方法:
- 在PubMed,Scopus和EBSCO数据库 (开始至2023年12月) 进行系统的文献搜索.
- 由两个审查员进行独立选和数据提取,由第三名审查员进行仲裁.
- 使用JBI关键评估工具进行偏见风险评估.
主要成果:
- 从最初选的934篇文章中,包括了34项研究.
- 包括的研究涵盖了所有人口统计数据中的多种人群 (9至298,433名患者).
- 芬太尼,吗啡, oxycodone,特拉马多尔和hydrocodone通常与不良事件有关.
结论:
- 阿片类药物,特别是芬太尼,吗啡和氧化,经常与可预防的药物不良反应,滥用和药物错误有关.
- 显著的数据异质性在得出最终结论方面带来了挑战.
- 强有力的预防策略和持续的研究对于减轻与阿片类药物相关的危害至关重要.
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