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导航临床前模型和外围神经病变的药物:一篇评论

Abdulmajeed M Jali¹, David Banji¹, Otilia J F Banji²

¹Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

Pharmaceuticals (Basel, Switzerland)

|August 29, 2024

概括

对于外围神经病变 (PN) 研究的临床前模型是有希望的,但也有局限性. 开发准确的模型对于推进治疗开发和优化这种复杂的神经疾病的治疗结果至关重要.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

周围神经病变 (PN) 涉及神经损伤,导致疼痛,软弱和自主性问题.
临床前模型对于理解PN和开发新治疗方法至关重要.
目前的模型在复制人类PN复杂性的能力上有所不同.

研究的目的:

审查和评估外围神经病研究的临床前模型.
评估这些模型对人类疾病的相关性.
确定它们在PN治疗开发中的有用性.

主要方法:

对各种PN临床前模型的现有文献的审查.
对链毒素 (STZ) 诱导的糖尿病神经病变模型的分析.
对化疗诱导的周围神经病变 (CIPN) 模型 (cisplatin,paclitaxel) 的评估.
对手术/创伤引起的神经损伤模型的评估.
在这些模型中对药物疗效研究 (加巴丁,普雷加巴林,杜洛丁,弗洛克塞丁) 的审查.

主要成果:

STZ模型在复制糖尿病神经病变的发病和进展方面存在局限性.
西斯普拉丁和帕克利塔克塞尔模型对CIPN研究有价值,但可能无法捕捉所有缺陷.
手术/创伤模型有助于理解神经再生.
几种药物在临床前环境中显示出治疗的前景.

结论:

没有单一的临床前模型完全复制人类外围神经病变.
每个模型都为PN的特定方面提供了独特的见解.
持续改进和综合方法对于有效的药物发现和治疗优化至关重要.

关键词:

优势优势优势缺点缺点缺点药物诱导诱导的药物诱导遗传学遗传学遗传学遗传学是一个非遗传性的非遗传性疾病周围神经病变 (Peripheral Neuropathy) 是一种神经病变.在临床前的模型中.

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