尼费迪平改善了饮食对大鼠胰岛素抵抗诱导的认知功能障碍的影响
Nancy M Abdel-Kareem1, Shimaa M Elshazly2, May A Abd El Fattah3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University-Arish Branch, Arish 45511, Egypt.
Pharmaceuticals (Basel, Switzerland)
|August 29, 2024
概括
高果糖摄入导致胰岛素抵抗和认知能力下降. 尼菲迪平与正常饮食一起改善了老鼠的认知功能和胰岛素抵抗,这表明了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 高果糖消费诱导胰岛素抵抗,对认知功能产生负面影响.
- 尼菲迪平是一种通道阻塞剂,在神经系统疾病中具有潜在的应用.
- 了解饮食干预措施与药物治疗一起对于管理认知功能障碍至关重要.
研究的目的:
- 为了研究尼菲迪平与正常饮食 (ND) 或性饮食 (KD) 结合对男性Wistar大鼠饮食诱导的胰岛素耐药性和认知功能障碍的影响.
- 评估这些干预措施对关键生物标记物的影响,包括来自大脑的神经营养因子 (BDNF),糖原合成酶激酶-3β (GSK3β),胰岛素降解酶 (IDE),粉样蛋白-β (Aβ) 和陶蛋白.
主要方法:
- 雄性Wistar大鼠在饮用水中食10%的果糖8周以诱导胰岛素抵抗.
- 随后,大鼠接受了尼菲迪平 (5.2 mg/kg/day) 口服,与正常饮食 (ND) 或性饮食 (KD) 一起,再服用5周.
- 数据使用单向和双向ANOVA进行分析.
主要成果:
- 回归ND显著改善了胰岛素耐药性,脂质特征,BDNF,GSK3β和IDE水平.
- 与ND一起的尼菲迪平的使用增强了认知行为和改善了胰岛素抵抗.
- 虽然与KD相比,nifedipine与ND并没有在所有参数中产生类似的改善,但它改善了GSK3β,Aβ和tau蛋白水平,这表明它在缓解神经病理标志物方面发挥了作用.
结论:
- 尼菲迪平与正常饮食相结合,有效地减轻了老鼠的胰岛素抵抗,并改善了它们的认知行为.
- 尼菲迪平-基因饮食组合显示,它有望减少像粉样蛋白-β和蛋白这样的病理标志物.
- 一种潜在的治疗策略包括短期的性饮食,随后是尼菲迪平治疗与正常饮食,以控制胰岛素抵抗和认知衰退.
关键词:
认知功能障碍 认知功能障碍果糖是葡萄糖中的一种.胰岛素耐药性是一种胰岛素耐药性.基因饮食是什么 基因饮食是什么尼菲迪平因 (nifedipine) 是一种尼菲迪平因 (nifedipine) 的一种药物.更多相关视频
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