关于疑似SARS-CoV-2病例中鼻鼻菌组合的见解
Librada A Atencio1, Indira J Quintero1, Alejandro Almanza1
1Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT), Clayton, Panama City 0843-01103, Panama.
Pathogens (Basel, Switzerland)
|August 29, 2024
概括
鼻喉细菌社区组成显示,COVID-19阳性和阴性患者之间没有显著差异. 在患有严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的患者中,特定的细菌系被丰富或耗尽.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 人类健康 人类健康 人类健康
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行已经激发了广泛的研究,但鼻口微生物群仍然是一个研究不足的领域.
- 了解上呼吸道微生物群落对于理解病毒感染期间宿主-病原体相互作用至关重要.
研究的目的:
- 分析疑似感染SARS-CoV-2的个体鼻鼻喉中的细菌群体组成.
- 调查鼻口微生物群与SARS-CoV-2检测状态,年龄和患者状况之间的潜在相关性.
主要方法:
- 巴拿马50例疑似SARS-CoV-2病例的鼻口样本的细菌社区组成分析.
- 使用线性差异分析效应大小 (LEfSe) 对α和β多样性的统计分析和生物标志物探索.
主要成果:
- 在SARS-CoV-2检测和未检测组之间,或根据年龄和患者状况,没有观察到总体细菌α和β多样性的显著差异.
- 像 *Corynebacterium*, *Staphylococcus*, *Prevotella*, *Streptococcus* 和 *Tepidiphilus* 这样的品种在两个群体中都是丰富的.
- 在LEfSe分析中,检测到的SARS-CoV-2患者中发现了*Veillonella*和*Prevotella*的丰富,而在未检测到的患者中发现了*Thermoanaerobacterium*和*Haemophilus*的丰富. 在检测到的SARS-CoV-2患者中, *Corynebacterium* 的数量减少.
结论:
- 虽然整体多样性仍然相似,但纳索-耳喉中的特定细菌种群可能与SARS-CoV-2感染状态有关.
- 这些发现凸显了鼻口微生物群在COVID-19背景下的潜在作用,并要求进一步调查.
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