在美国各地的烧伤中心 (MICROBE) 对生物多样性和难以治疗的病原体进行多中心,回顾性研究的试点分析
1Department of Pharmacy, Regional One Health, Memphis, TN 38103, USA.
Pathogens (Basel, Switzerland)
|August 29, 2024
概括
患有烧伤的患者面临难以治疗的病原体 (DTP) 的高风险. 以前的抗生素暴露显著增加了发展这些耐药性感染的可能性,影响了患者的结果.
科学领域:
- 传染性疾病 传染性疾病
- 烧伤护理 烧伤护理
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 烧伤显著增加感染风险,通常涉及难以治疗的病原体 (DTp).
- 了解导致DTp发展的因素对于改善患者在烧伤护理方面的结果至关重要.
研究的目的:
- 为了确定烧伤患者中DTp的发生率.
- 为了确定与DTp发展相关的因素,包括先前的抗菌药物暴露.
- 分析DTp对患者结局的影响.
主要方法:
- 对烧伤患者的回顾性单中心研究,具有需要治疗的阳性培养.
- 收集的人口统计数据,病原体概况和抗菌素暴露史.
- 根据已确定的抗微生物耐药性标准 (MDR,XDR,MRSA,ESBL等) 定义的DTp. ) 的情况.
主要成果:
- 隔离的病原体中有56.7%被归类为DTp.
- 之前暴露于局部和全身抗微生物药物与DTp发展有显著的关联.
- 在DTp患者中观察到死亡率增加的趋势 (Log排名p = 0.0583).
结论:
- 以前使用抗生素是发展难以治疗的病原体的重要风险因素.
- 这些发现强调了在烧伤护理中需要对抗微生物药物的管理.
- 结果将为更大规模的,多中心的关于烧伤感染和耐药性的研究提供信息.
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