对艾滋病毒诊断的错失机会及其在葡萄牙人口中的临床影响-一项队列研究
João Lourinho1,2, Maria João Miguel1, Frederico Gonçalves1
1Infectious Diseases Department, Hospital Garcia de Orta, ULS Almada-Seixal, 2805-267 Almada, Portugal.
Pathogens (Basel, Switzerland)
|August 29, 2024
概括
人类免疫缺陷病毒 (HIV) 的晚期诊断与错过的机会有关. 这些错失的机会在诊断时显著增加了艾滋病定义条件的风险,强调了有针对性的干预措施的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 人类免疫缺陷病毒 (HIV) 的晚期诊断是一个重大的公共卫生问题.
- 错过了早期诊断的机会,经常与疾病在呈现时的晚期有关.
研究的目的:
- 评估早期人类免疫缺陷病毒 (HIV) 诊断在成年人中错过的机会.
- 评估这些错失机会的临床影响,特别是艾滋病定义条件.
主要方法:
- 追溯的,纵向的,单中心的队列研究.
- 包括436名新确诊艾滋病毒或未使用过毒品的成年人 (2018-2023年).
- 评估在诊断或最后一次阴性测试前两年错过的机会;临床/实验室数据的比较.
主要成果:
- 27.1%的人至少一次错过了早期艾滋病毒诊断的机会.
- 错过的机会与女性,年龄较大,非洲血统,艾滋病毒流行率高的国家和异性传播有关.
- 错过的机会显著增加了在诊断时患有艾滋病的可能性 (OR 3.23,p < 0.001).
结论:
- 错过了早期人类免疫缺陷病毒 (HIV) 诊断的机会对疾病的严重程度产生了重大影响.
- 有针对性的干预措施对于减少错失机会和改善患者在艾滋病毒治疗中的结果至关重要.
更多相关视频
19:57An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
18.5K
13:58Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
31.5K
相关概念视频
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
Sexually Transmitted Infections
286
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
286
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Immunodeficiency Diseases
926
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
926
