临床相关的特征和对痛和其他抗过敏鼻喷雾剂的比较
Virginia Patterlini1, Fabiola Guareschi1, Davide D'Angelo1
1Dipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Pharmaceutics
|August 29, 2024
概括
这项研究比较了鼻喷雾配方,发现Ryaltris比Dymista具有更高的粘度和更快的皮质类固醇溶解,这表明对过敏性鼻炎治疗的潜在临床益处.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 过敏性鼻炎治疗药物 治疗药物
背景情况:
- 鼻腔皮质类固醇悬浮剂对于治疗过敏性鼻炎至关重要.
- 传统的表征方法不足以评估药物的沉积,停留时间和溶解.
- 了解这些参数是优化体内疗效的关键.
研究的目的:
- 为了从技术上描述Ryaltris (mometasone furoate/olopatadine HCl) 鼻喷雾剂.
- 为了比较Ryaltris与Dymista (azelastine HCl/fluticasone propionate),Nasonex (mometasone furoate) 和Avamys (fluticasone furoate) 的使用情况.
- 评估药物溶解,粘度,流量和鼻内沉积的概况.
主要方法:
- 结合了创新技术 (Respicell®装置) 和传统技术.
- 使用Respicell®装置评估溶解概况.
- 测量了配方粘度,在倾斜的平面上流动,并通过鼻腔件进行鼻内沉积.
主要成果:
- 在鼻喷雾剂中观察到显著的粘度和溶解率在体外显著差异.
- 与其他产品相比,Ryaltris的粘度更高,流量更低.
- 瑞尔特里斯的溶解率比迪米斯塔更快,皮质类固醇的溶解率更快.
结论:
- 应用的表征方法成功地区分了鼻喷雾产品.
- 瑞亚特里斯的粘度,流量和溶解概况表明,对过敏性鼻炎的临床性能有潜在的优势.
- 需要进一步的临床研究来证实治疗效益.
更多相关视频
相关概念视频
01:15Upper Respiratory Drugs: First and Second-Generation Antihistamines
226
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
226
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
251
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
251
01:16Drugs Used in Upper Respiratory Disorders: Overview
190
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
190
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
239
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
239
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
228
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
228
01:19Antiasthma Drugs: Leukotriene Modifiers
253
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
253