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生物聚合物胰岛素膜用于抗微生物,抗氧化剂和伤口愈合应用

Rocío Aguilar-Vázquez¹, Alejandra Romero-Montero¹, María L Del Prado-Audelo²

¹Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.

|August 29, 2024

概括

这项研究开发了一种带有胰岛素的新型生物聚合物膜,用于增强伤口愈合. 载有胰岛素的膜在体外和体内都显示出伤口关闭的显著改善,提供了一个有前途的新疗法.

科学领域:

生物材料科学生物材料科学
药物运输药物运输药物运输
再生医学是一种再生医学.

背景情况:

伤口愈合延迟会造成感染风险,需要改进治疗策略.
药物重新定位和可生物降解的伤口带为先进的伤口护理提供了有希望的途径.
现有的治疗方法可能无法完全解决慢性伤口管理的紧迫性.

研究的目的:

为了研究重新定位的胰岛素融入生物聚合物膜的伤口愈合潜力.
为了评估胰岛素在一种新的伤口剂配方中的性作用.
开发和描述一种多功能生物聚合物膜,用于加速伤口关闭.

主要方法:

生物聚合物膜的制造使用酸,香甘,瓜尔,甘油和.
加入人体胰岛素与波洛克萨默188作为稳定剂.
综合性表征包括物理化学,机械,抗氧化,抗菌,细胞活力,以及体外/体外伤口愈合分析.

主要成果:

开发的膜显示出出色的机械性能,高胀能力 (1100%),30%的抗氧化活性.
观察到对*S. aureus* (85%抑制) 和*P. aeruginosa* (75%抑制) 的显著抗菌活性.
胰岛素在体外 (5.5倍增加) 和体内 (3.2倍增加) 显著加快了伤口关闭,在10天内92%的伤口关闭.

结论:

成功开发了一种新型的含胰岛素的生物聚合物膜,证明了多功能伤口愈合能力.
胰岛素在伤口关闭和抗氧化活性中的作用,增强了波洛克萨默188的抗菌作用,突出了其治疗潜力.
这种创新材料显示出作为先进的伤口愈合治疗方法的前景,特别是在慢性伤口.

关键词:

它具有抗菌活性,具有抗菌活性.抗氧化剂是一种抗氧化剂.药物重新定位药物重新定位在体外 (in vitro) 的情况下.在活体中,活体中在这种情况下,胰岛素胰岛素胰岛素.波洛克萨默 188 188 年聚合物膜的聚合物膜.伤口愈合伤口愈合

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