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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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用于向癌症治疗的功能化聚合物微粒:从概念化到临床试验的步骤

Ana Serras1, Célia Faustino1, Lídia Pinheiro1

  • 1Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa (ULisboa), Avenida Professor Gama PintoGama Pinto, 1649-003 Lisboa, Portugal.

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概括

聚合物微粒 (PMs) 提供了一个有前途的纳米医学方法来克服化疗的局限性. 这些智能药物输送系统 (SDDS) 提高了药物的有效性和安全性,使癌症治疗从临床前阶段向临床阶段推进.

关键词:
两性聚合物的两性聚合物.癌症 癌症 癌症 癌症 癌症临床试验是指临床试验中的临床试验.纳米医药是一种纳米医药.聚合物米塞尔的结构刺激对刺激有反应的菌体.有针对性的药物输送.

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科学领域:

  • 纳米医学和药物输送系统
  • 瘤学 治疗学 治疗学

背景情况:

  • 癌症仍然是导致死亡的主要原因,化疗面临毒性,生物可用性差,多药性耐药性等挑战.
  • 纳米医学已经成为开发具有改进性质的先进治疗方法的领域.
  • 智能药物输送系统 (SDDS) 对于提高药物输送和治疗结果至关重要.

研究的目的:

  • 审查聚合物微粒 (PMs) 作为一种特定类型的SDDS用于癌症治疗.
  • 专注于已经从临床前研究进展到临床试验的PM.
  • 检查基于PM的纳米治疗药物的市场引入之路.

主要方法:

  • 科学文献的审查,重点关注纳米医学和癌症治疗中的聚合物微粒.
  • 对基于PM的纳米治疗药物的临床前数据和临床试验进展的分析.
  • 评估从实验室研究到临床应用的开发途径.

主要成果:

  • 聚合物微粒有效封装疏水性和有毒药物,提高稳定性和生物可用性.
  • 临床前研究表明,增强的药物动力学特征,增加的治疗疗效,提高了PMs的安全性.
  • 几种PM配方正在通过临床试验取得进展,表明它们的治疗潜力.

结论:

  • 聚合物微粒代表了纳米医学在癌症治疗中的重大进步.
  • PMs显示出克服传统化疗的主要局限性的潜力.
  • PMs进入临床试验的进展凸显了它们对未来癌症治疗的承诺.