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没有上腺素的缓冲局部麻醉剂:开发,表征和体内疗效和毒性分析
Daniel Uzbelger Feldman1, Billy B Laun2, Chirag Patel3
1Department of Endodontology, Temple University Kornberg School of Dentistry, 3223 N. Broad Street, Philadelphia, PA 19140, USA.
Pharmaceutics
|August 29, 2024
概括
开发了一种没有上腺素 (LW/O/E) 的新型牙麻醉剂,改善了味道并保持了疗效. 这种缓冲性,更高的度注射剂为牙痛管理提供了传统利多卡因与上腺素的有希望的替代品.
科学领域:
- 药理学 药理学是指药理学的学科.
- 牙科麻醉 牙科麻醉
- 配方科学科学 配方科学
背景情况:
- 利多卡因化与上腺素 (LW/E) 自1948年以来一直是标准的牙科麻醉剂.
- 现有的配方与注射刺痛,苦味和缓慢发病有关.
- 几十年来,LW/E没有引入任何重大修改.
研究的目的:
- 设计和描述一个改进的牙科利多卡因化注射配方,没有上腺素 (LW/O/E).
- 通过解决口味和注射相关问题来提高患者的舒适性.
- 评估新型配方的疗效,持续时间和安全性.
主要方法:
- 使用缓冲剂,甜味剂和氨基酸的LW/O/E配方,目标pH为6.5-7.0和度为590-610mOsm/kg.
- 使用电子舌头 (ETongue) 对粘度,可注射性和味道进行表征.
- 在Sprague Dawley大鼠 (SDR) 中体内评估麻醉疗效 (辐射热尾延迟,热板试验) 和局部毒性.
主要成果:
- 在LW/O/E样本中,粘度和注射能力与LW/E样本相似.
- 舌头分析显示,LW/O/E配方的苦味显著减少.
- 在体内研究表明可比的麻醉持续时间和轻微的,暂时的局部毒性优化LW/O/E (样本3A).
结论:
- 开发的LW/O/E配方 (样本3A) 显示了改善的味道特征和与LW/E相比的麻醉疗效.
- 这种新的配方,具有缓冲,更高的度和减少的苦味,为牙科麻醉提供了可行的替代方案.
- 需要进一步的临床评估来确认其适用性,以取代含上腺素的利多卡因.
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