植物医药的新型药物输送系统
Xingwang Zhang1, Wei Wu2,3
1Department of Pharmaceutics, School of Pharmacy, Jinan University, No. 855 East Xingye Avenue, Guangzhou 511443, China.
Pharmaceutics
|August 29, 2024
概括
植物药物是活性药物成分 (API) 的来源. 本研究探讨了药用植物的API的起源和发现,强调了它们的治疗潜力.
科学领域:
- 植物化学和天然产品化学
- 药理学是指药理学,即药理学是指药理学.
- 药物发现 药物发现 药物发现
背景情况:
- 从历史上看,药用植物一直是治疗化合物的主要来源.
- 现代药物发现越来越多地重新审视植物药物,寻找新的活性药物成分 (API).
- 了解植物的植物化学特征对于识别化合物至关重要.
研究的目的:
- 研究各种植物药物中存在的活性药物成分 (API).
- 为了确定这些API的植物起源.
- 探索植物药物作为新药发现的可持续来源的潜力.
主要方法:
- 关于民族植物学和植物化学研究的文献综述.
- 化学分析技术,如高性能液体染色学 (HPLC) 和质谱学 (MS).
- 隔离化合物的生物活性选.
主要成果:
- 从各种植物物种中识别了众多的API.
- 传统医疗用途与已识别的活性化合物之间的相关性.
- 证明了几个植物性化合物的显著药理活性.
结论:
- 植物药物代表着各种API的丰富储备.
- 对药用植物的系统研究可以导致发现新的治疗剂.
- 对植物化学的进一步研究有望促进制药科学的发展.
相关概念视频
01:16Drug Delivery: Overview
279
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
279
01:22Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
01:18Drug Delivery: Enteral Route
395
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
395
01:28Biopharmaceutics and Pharmacokinetics: Overview
1.9K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.9K
01:18Routes of Drug Administration: Enteral
3.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.4K
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
476
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
476