口服使用的柏柏林化水基基托/氧甲基-β-环氧德克斯水凝
Bukatuka Futila Clemence1, Lin Xiao2, Guang Yang1
1Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Polymers
|August 29, 2024
概括
一种新型的奇托桑/碳甲基-β-环氧化水凝有效地通过口服提供柏柏林化. 这种配方增强了溶解性,提供持续释放,并表现出抗菌性质,没有观察到细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 柏柏林化物 (BBH) 具有治疗潜力,但其口服生物可用性和溶解性不佳.
- 需要有效的口服输送系统来利用BBH的好处.
- 奇托 (CS) 和碳氧甲基-β-环氧 (CMCD) 是具有水凝形成潜力的生物相容聚合物.
研究的目的:
- 为了合成和描述一种新的口服水凝配方,用于甲酸 (BBH) 输送.
- 评估开发的水凝的可溶性,药物释放特征,抗菌活性和细胞毒性.
- 评估CS/CMCD/BBH水凝对于有效的口服药物输送的潜力.
主要方法:
- 基托 (CS) 和碳氧甲基-β-环极 (CMCD) 的物理交联形成水凝矩阵.
- 将柏柏林化物 (BBH) 装入合成的CS/CMCD水凝中.
- 描述水凝的物理特性,药物加载效率和体外药物释放动力学.
- 对抗*大肠杆菌*,金黄色葡萄球菌*和白虫*的抗菌活性的评估.
- 使用NIH3T3和HaCaT细胞系进行体外细胞毒性评估.
主要成果:
- 成功合成了一种装有BBH的CS/CMCD水凝复合物 (CS/CMCD/BBH).
- 水凝证明了BBH溶解度的提高和持续的药物释放概况.
- 观察到对测试的病原体 (*大肠杆菌*, *金黄色杆菌*, *C.albicans*) 有显著的抗菌活性.
- 在体外研究中没有显示对NIH3T3和HaCaT细胞的细胞毒性,表明良好的生物相容性.
结论:
- 开发的CS/CMCD/BBH水凝是一种有前途的平台,可以通过口服输送柏柏林化.
- 水凝增强了BBH的溶解性,确保持续释放,并具有抗菌性质.
- 该配方的安全性和有效性表明其在各种生物医学领域的潜在应用,这些领域需要口服BBH.
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