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设计和优化3D打印含有粘液提取物用于勃起功能障碍管理的3D打印平板电脑:美国能源部指导的一项研究

Ratchapoom Wattanawiggan¹, Sunee Chansakaow¹, Pensak Jantrawut¹

¹Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Plants (Basel, Switzerland)

|August 29, 2024

概括

半固体挤出3D打印成功创建了用于治疗勃起功能障碍 (ED) 的持续释放药片,使用Mucuna提取物. 这种3D打印方法确保了持续的活性成分输送和受控的药物释放,以提供可靠的ED治疗.

科学领域:

制药技术制药技术制药技术
药物输送系统药物输送系统
3D打印在医学中的应用

背景情况:

勃起功能障碍 (ED) 是一种影响性活动的疾病,Mucuna (M. pruriens) 提取物由于其利沃多巴含量显示出治疗潜力.
由于其固有的半固体性质,将Mucuna提取物制成常规药片是具有挑战性的.
需要新的药物输送系统来克服配方挑战并提高治疗疗效.

研究的目的:

使用半固体挤出3D打印开发Mucuna提取物持续释放片.
调查配方参数对可打印性和药物释放特性的影响.
优化3D打印过程,以实现可靠和一致的平板电脑生产.

主要方法:

半固体挤出3D打印技术被用于制造含有Mucuna提取物的药片.
欧德拉吉特RSPO和聚 (乙烯基酒精) (PVA) 被用作持续释放的聚合物用于平板电脑矩阵.
实验设计 (DoE) 用于选可打印性因素并优化莱沃多巴释放和一致性.

主要成果:

可打印性受到聚合物固体百分比含量 (PSPC) 和尤德拉吉特-PVA比率的显著影响.
所有测试的配方均表现出成功的可打印性.
一个优化的配方58.8%PSPC和Eudragit-PVA比率为2.87:1实现了目标的利沃多巴释放和一致性.

结论:

半固体挤出3D打印是一种可行的技术,用于生产用Mucuna提取物3D打印的平板.
能源部的方法有效地指导了3D打印过程的优化.
这种方法可以可靠地制造出含有一致活性成分的药片,并为ED治疗提供所需的释放特征.

关键词:

通过3D打印打印3D打印.美国能源部 (DoE)这是一种Mucuna提取物.这是勃起功能障碍.优化的优化优化优化.持续释放持续释放持续释放

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