莫林加叶的抗病毒特性 叶片提取物对抗呼吸道病毒
Rosa Giugliano1, Valeria Ferraro2, Annalisa Chianese1
1Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Viruses
|August 29, 2024
概括
莫林加橄树叶提取物,特别是来自萨伦托品种的叶子提取物,对人类冠状病毒229E和麻疹病毒表现出强大的抗病毒活性. 微波辅助提取产生较少的细胞毒性化合物,有效抑制病毒进入.
科学领域:
- 植物化学 植物化学
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 植物是生物活性化合物的丰富来源,用于药物发现.
- 莫林加 (M. oleifera) 以其药用和非药用益处而闻名.
- 病毒感染对全球健康构成重大挑战.
研究的目的:
- 评估M. oleifera叶片提取物对HCoV-229E和MeV的抗病毒性能.
- 通过化和微波辅助提取 (MAE) 获得的提取物的疗效和细胞毒性进行比较.
- 确定负责抗病毒活性的关键生物活性化合物.
主要方法:
- 两种M. oleifera品种 (萨伦托,巴列塔) 采用和MAE提取.
- 对Vero CCL-81和Vero/SLAM细胞的细胞毒性评估.
- 针对HCoV-229E和MeV的抗病毒检测.
- 高性能液体色谱 (HPLC) 用于化合物识别.
主要成果:
- MAE 提取物表现出比化提取物更低的细胞毒性.
- 这两种提取物类型都抑制了HCoV-229E和MeV感染,阻止病毒的进入.
- 萨伦托品种表现出高疗效,其IC50值为HCoV-229E的21μg/mL,MeV的6μg/mL.
- 在HPLC中确定了基酸,新基酸,QGP和转基因.
结论:
- M. oleifera 提取物对呼吸道病毒具有显著的抗病毒潜力.
- MAE是减少细胞毒性的首选提取方法.
- 萨伦托品种是抗病毒药物开发的有力来源.
- M. oleifera可能通过破坏病毒颗粒和抑制细胞融合而起作用.
关键词:
在HPLC中使用HPLC.马克·奥利弗雷拉 (M. oleifera) 是一个抗病毒活动的抗病毒活性.冠状病毒冠状病毒的新冠病毒.麻疹病毒的病毒微波辅助提取方式 微波辅助提取方式自然产品是自然产品的产品.呼吸道病毒的病毒.更多相关视频
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