在注射药物的肝炎病毒患者中对医疗保健系统的不信任和坚持直接作用的抗病毒治疗C病毒
Akhila Padi1, Irene Pericot-Valverde2,3, Moonseong Heo4
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Viruses
|August 29, 2024
概括
在注射药物使用者 (PWID) 中,对医疗保健的不信任对型肝炎治疗的坚持有负面影响. 建立信任对于改善这种人群对直接作用抗病毒药物 (DAA) 治疗的坚持至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 型肝炎病毒 (HCV) 影响边缘化人口,包括注射药物使用者 (PWID).
- 直接作用抗病毒药物 (DAA) 提供有效的HCV治疗,但在特定人群中,坚持治疗可能具有挑战性.
- 对医疗保健系统的不信任可能会阻碍PWID患者坚持治疗.
研究的目的:
- 调查医疗保健系统不信任对直接作用抗病毒药物 (DAA) 在注射药物 (PWID) 的人群中对型肝炎病毒 (HCV) 治疗的坚持的影响.
主要方法:
- 一项随机临床试验的二次分析,该试验涉及纽约市150名PWID患者.
- 不信任被测量使用一个9项仪器.
- 使用电子泡包评估了药物坚持.
主要成果:
- 在较高的不信任程度和药物坚持之间观察到显著的反向关系 (71.8%与77.9%,p=0.024).
- 不信任与社会人口统计或物质使用特征没有显著的关联.
- 较低的不信任程度与更高的坚持DAA相关.
结论:
- 建立对医疗保健系统的信任对于改善PWIDs中的DAA遵守是必不可少的.
- 建议以患者为中心的护理,敏感培训和卫生系统改革来满足这一群体的需求.
- 对PWID的有效的HCV治疗策略必须包含建立信任的倡议.
相关概念视频
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Sexually Transmitted Infections
286
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
286
Healthcare Agencies II
692
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
692
Routes of Drug Administration: Parenteral
1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K


