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登革热病毒血清型-1/基因型-I在埃塞俄比亚东部和东南部的占主导地位

Mesfin Mengesha Tsegaye^1,2, Adamu Tayachew Mekonnen³, Daniel Tsega Gebretsion³

¹Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.

|August 29, 2024

概括

登革热病毒 (DENV) 血清型1和2在埃塞俄比亚流传. 确定了DENV-1基因型-I和基因型-III,以及DENV-2宇宙基因型菌株,显示了局部传播和与区域菌株的相关性.

科学领域:

医学病毒学医学病毒学
流行病学流行病学
基因组监测基因组监测

背景情况:

登革热病毒 (DENV) 爆发在埃塞俄比亚构成了严重的公共卫生威胁.
了解循环的血清型和基因型对于有效的疾病控制至关重要.

研究的目的:

在迪雷达瓦市和索马里地区爆发期间确定DENV血清型和基因型.
分析埃塞俄比亚DENV菌株与区域和全球菌株的遗传相关性.
评估DENV血清型的本地传播模式和共同循环.

主要方法:

分析了2014-2016年和2021年登革热爆发期间存档的血清样本.
使用分子方法进行DENV血清型和基因型鉴定.
遗传学分析以确定遗传关系.

主要成果:

DENV血清型1 (DENV-1) 是主要的,其次是DENV血清型2 (DENV-2).
DENV-1菌株属于基因型I和基因型III;DENV-2菌株是宇宙基因型.
流通的菌株与邻国和亚洲国家的菌株有着密切的遗传关系.
有证据表明,DENV-1和DENV-2的局部传播和共同循环仍在继续.

结论:

埃塞俄比亚登革热疫情是由DENV-1和DENV-2驱动的,它们具有特定的基因型.
遗传数据表明正在进行的本地传播和来自邻近地区的潜在引入.
加强基因组监测对于早期检测和预防未来DENV爆发至关重要.

关键词:

埃塞俄比亚埃塞俄比亚埃塞俄比亚体/前膜 (CprM) 是一种登革热病毒感染者基因型基因型基因型疫情爆发的原因是遗传学分析遗传学分析这是一个序列的序列.血清型的血清型是什么

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