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在急性缺血性中风中对质栓塞类型的超粘弹性单轴性特征

Jose L Monclova¹, Daniel J Walsh¹, Terrell Barraclough¹

¹Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.

Journal of the mechanical behavior of biomedical materials

|August 29, 2024

概括

这项研究描述了凝块类型的机械特性,发现原蛋白显著增加了性. 这些发现有助于开发更好的机械血栓切除术在中风治疗中的模型.

科学领域:

生物医学工程生物医学工程
机械工程机械工程
神经科学是一个神经科学.

背景情况:

急性缺血性中风是一个主要的全球健康问题,不完全的血管再通道发生在约30%的机械血栓切除手术中.
凝块的组成越来越被认为是影响机械血栓切除术成功率的关键因素.

研究的目的:

在不同的形成条件下,对栓类型 (EAs) 的速度依赖,高应变的机械行为进行描述.
在体外开发EAs,准确地模仿体内血块的机械和结构性质,以改善超粘弹性建模.

主要方法:

研究了原透对EA高应变硬度的影响,将其与40%的血红素EA进行比较.
使用单轴负载框架测量EA高应变刚度.
应用超粘弹性曲线适配来建模观察到的机械行为.

主要成果:

与非原体类似物相比,原体凝块类似物在高应变硬度上表现出一个数量级的增加.
钱德勒循环类似物表现出与患者凝块一致的机械性质和组成,原凝块显著更硬.
非线性,取决于速率的超粘弹性模型,包括凝块刚性和弹性能量稳定性,为高应变,取决于速率的数据提供了良好的适合性.

结论:

建立了一个创建动态形成EA的框架,复制体内凝块的机械和结构特征.
提供了在中风治疗研究中使用超粘弹性模型增强血栓行为的数值模拟的基本参数.

关键词:

凝块是因为凝块.原蛋白是一种原蛋白.在这里,先生,先生,先生.在 Ogden 和 Ogden 里面.一次性中风,中风.粘性弹性粘性弹性的

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