相关实验视频

Updated: Jun 14, 2025

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform

Published on: November 9, 2017

儿童多系统炎症疾病中的长期细胞因子概况

Valeria Calcaterra¹, Cristian Loretelli², Davide Biganzoli³

¹Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Pediatric Department, Buzzi Children's Hospital, Milano, Italy.

|August 29, 2024

概括

患有多系统炎症综合征 (MIS-C) 的儿童在感染一年后表现出持续升高的细胞因子水平,表明正在进行的炎症和潜在的长期代谢问题.

科学领域:

儿科免疫学儿科免疫学
传染性疾病传染性疾病
后传染性综合征后传染性综合征

背景情况:

儿童多系统炎症综合征 (MIS-C) 是COVID-19之后的一种严重疾病.
目前尚不完全了解MIS-C的长期结果,尤其是免疫反应.
了解细胞因子概况对于评估MIS-C的影响至关重要.

研究的目的:

在诊断时和12个月的随访期间,分析儿科MIS-C患者的细胞因子概况.
探索细胞因子水平和生化/荷尔蒙标志物之间的相关性.
了解MIS-C.的长期免疫后果.

主要方法:

在25名MIS-C患者中分析了细胞因子水平 (IL-9,eotaxin,IP-10,MIP-1β,RANTES,MCP-1,TNF-α,PDGF-B,IL-4,MIP-1α).
诊断时收集的数据,诊断后的6个月和12个月.
与标准生化和荷尔蒙测试相关联的细胞因子数据.

主要成果:

某些细胞因子 (IP-10,MCP-1,MIP-1α) 在12个月后正常化.
与对照组相比,其他细胞因子 (IL-9,eotaxin,MIP-1β,RANTES,TNF-α,PDGF-B,IL-4) 的水平仍然较高.
在细胞因子和代谢标记物 (甘油三,HOMA-IR,葡萄糖) 和激素 (皮质醇,ACTH) 之间发现了相关性.

结论:

儿科MIS-C患者至少12个月表现出持续的,细胞因子驱动的炎症反应.
确定了细胞因子和代谢/激素模式之间的相互关系.
持续的炎症可能会导致急性器官损伤和长期代谢障碍.

关键词:

在 COVID-19 疫情中,孩子孩子孩子孩子复杂性复杂性复杂性细胞因子 (cytokines) 是一种细胞因子.长期跟进长期跟进多系统炎症疾病多系统炎症疾病

更多相关视频

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...