阶段角度是头癌手术后整体5年生存率的预测指标
Neyara Dos Santos Oliveira1, Marcelo Leandro Santana Cruz2, Ramon Silva de Oliveira2
1Universidade Estadual de Feira de Santana (UEFS), Feira de Santana, BA, Brazil.
Brazilian journal of otorhinolaryngology
|August 29, 2024
概括
阶段角 (PhA) 是头癌 (HNC) 患者接受手术生存的关键预测因素. 较低的手术前PhA表明死亡风险较高,突出显示了它在HNC预后中的重要性.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 头癌 (HNC) 给患者带来了重大生存挑战,特别是在手术治疗后.
- 营养状况和身体成分越来越被认为是影响HNC患者结果的关键因素.
- 生物电阻分析 (BIA) 变量提供了一种非侵入性方法来评估身体组成和细胞完整性.
研究的目的:
- 调查肌肉质量百分比 (%MM),身体脂肪百分比 (%BF),相位角 (PhA) 和标准化相位角 (SPhA) 对手术治疗HNC患者的整体存活率的预测能力.
- 为了确定哪些BIA衍生参数在该患者队列中对生存风险分层最有效.
主要方法:
- 一项前性队列研究涉及78名手术治疗的HNC患者,该研究于2017年至2022年期间进行.
- 经验丰富的营养学家收集了手术前的数据,包括社会人口统计,临床,人体测量和BIA变量.
- 整体存活率在手术后跟踪到死亡,并定义了中位数随访时间.
主要成果:
- 在78名患者中,51.2%在随访期间死亡,平均存活时间为39个月.
- 虽然%MM,%BF和SPhA在幸存者和非幸存者之间没有显著差异,但相位角度 (PhA) 作为69%准确度的整体存活的独立预测指标.
- 手术前PHA低于6.8°的患者在随访期间死亡的可能性是两倍以上 (HR=2.38,p=0.02).
结论:
- 手术前阶段角度 (PhA) 是 HNC 手术后患者整体生存的有价值和独立的预测指标.
- 来自BIA的PhA测量可以帮助识别高NC患者的死亡风险较高,为临床管理和营养支持策略提供信息.
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