在Andrographis paniculata中,andrographolide在1年以上的储存时间内降解
Md Tanvin Ahammed1, Md Zakir Sultan2, Md Sabbir Hossain3
1Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Phytochemical analysis : PCA
|August 29, 2024
概括
安德罗格拉福利德 (Andrographolide) 是一种来自Andrographis paniculata的化合物,在一年内显著降解 (69.26%). 适当的储存条件对于保持这种草本提取物的药用功效至关重要.
科学领域:
- 植物化学 植物化学
- 药理学是指药理学,即药理学是指药理学.
- 分析化学 分析化学
背景情况:
- 安德罗格拉福利德是来自药用植物Andrographis paniculata的关键生物活性化合物.
- 传统上,Andrographis paniculata因其肝脏保护性质而闻名,并作为一种苦味增强剂.
研究的目的:
- 在一年的储存期内量化andrographolide的降解率.
- 为了确定影响储存植物材料中andrographolide稳定性的因素.
主要方法:
- 新鲜和一年大的Andrographis paniculata粉样品的比较.
- 使用乙醇提取andrographolide的提取方法.
- 通过高性能液体染色学 (HPLC) 量化安德罗格拉福利德度.
主要成果:
- 经过一年的储存后,观察到安德罗格拉福利德的显著逐渐降解69.26%.
- 存储温度和样本结晶度被确定为影响andrographolide降解率的关键因素.
结论:
- 长时间的储存会显著降低Andrographis paniculata中andrographolide的含量.
- 最佳的储存条件对于保持Andrographis paniculata提取物的治疗潜力和有效性至关重要.
关键词:
安德罗格拉菲斯 (Andrographis paniculata) 是一个恐慌的动物.在HPLC中使用HPLC.安德罗格拉福利德 (andrographolide) 是一种降解降解降解降解降解.长时间的储存储存.更多相关视频
05:59An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
1.7K
06:12Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
Published on: April 14, 2023
606
相关概念视频
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
3.1K
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
3.1K
01:16Drug Product Stability
376
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
376