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纳米粒子与KRAS纳米疫苗对抗乳腺癌进行协同作用

Cláudio Ferro^1,2, Ana I Matos¹, Luigia Serpico³

¹Research Institute for Medicines, iMed.Ulisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal.

Advanced healthcare materials

|August 29, 2024

概括

稳定的纳米颗粒 (SeNPs) 在癌症治疗方面表现有前途. 稳定牛血清白的SeNPs有效地减少了小鼠的瘤生长,突出了它们在癌症免疫治疗中的潜力.

科学领域:

纳米医学是一种纳米医学.
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

(Se) 对人类健康至关重要,具有抗癌性质.
纳米粒子 (SeNPs) 的毒性较低,生物相容性比其他化合物更高.
裸体SeNP在水溶液中缺乏稳定性,因此需要稳定策略.

研究的目的:

使用各种稳定剂开发稳定的纳米粒子 (SeNPs).
为了评估这些稳定SeNPs的抗癌潜力.
在临床前癌症模型中研究SeNPs与纳米疫苗结合的协同效应.

主要方法:

用牛血清白蛋白 (BSA),奇托和其他聚合物稳定球形SeNPs (<100nm) 的合成和表征.
在各种介质 (介质,血,生理pH) 中评估SeNP的稳定性.
在体外评估SeNP对癌细胞系和原发性人类皮肤纤维细胞的细胞毒性.
在体内对BSA-SeNPs与EO771乳腺癌小鼠模型中纳米疫苗结合的疗效研究.

主要成果:

优化的SeNP是球形的,<100nm,尺寸分布窄.
在酸性条件下产生的BSA稳定的SeNPs在各种生理条件下表现出优越的稳定性,保持大小为~50-60nm.
SeNPs对癌细胞具有选择性毒性,但不会影响正常的纤维细胞.
在小鼠模型中,与BSA-SeNPs和纳米疫苗的联合治疗显著降低了瘤生长 (减少了三倍).

结论:

经BSA稳定的SeNP是稳定的,并具有选择性的抗癌特性.
BSA-SeNPs与纳米疫苗的协同效应显示出显著的瘤减少,表明改善癌症免疫治疗的潜力.
这些发现支持SeNPs作为有效的抗癌剂和组合治疗策略的发展.

关键词:

乳腺癌乳腺癌乳腺癌免疫疗法免疫疗法纳米颗粒是一种纳米粒子.纳米疫苗的使用方法是一种.

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