在摩洛哥人口中遵守地中海饮食和结肠直肠癌风险:基于医院的病例控制研究
Hamza Elbaylek1, Soumia Ammor1
1Department of Biology, Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Faculty of Sciences Semlalia University Cadi Ayyad, Marrakech, Morocco.
Asian Pacific journal of cancer prevention : APJCP
|August 29, 2024
概括
坚持修改后的地中海饮食 (MMD) 在摩洛哥显著降低了结直肠癌 (CRC) 的风险. 高度的MMD坚持将CRC风险降低了61%,显示出其作为预防措施的潜力.
科学领域:
- 营养与癌症流行病学
- 公共卫生研究 公共卫生研究
- 地中海饮食研究 研究研究
背景情况:
- 结肠直肠癌 (CRC) 在摩洛哥是一个重大的公共卫生挑战.
- 地中海饮食 (MD) 在降低北地中海人口中CRC风险方面表现有前途.
- 一个修改的地中海饮食 (MMD) 评分被适应南方国家,以评估其在摩洛哥的影响.
研究的目的:
- 调查摩洛哥人口中遵守地中海饮食 (MD) 与结直肠癌 (CRC) 风险之间的关联.
- 评估为南方地区量身定制的修改地中海饮食 (MMD) 评分的有效性.
- 确定MD的遵守是否可以成为摩洛哥CRC的预防策略.
主要方法:
- 一项涉及395例CRC病例和395个匹配对照的病例控制研究.
- 通过调整的食物频率问卷来计算MMD得分,评估了饮食摄入量.
- 计算了几率比率 (OR) 和95%置信区间 (CI) 来评估MD-CRC风险关系.
主要成果:
- 观察到MD坚持和CRC风险之间存在显著的反向关联.
- 中度的MD坚持将CRC风险降低了52% (OR:0.48,95%CI:0.37-0.69).
- 高度的MD坚持将CRC风险降低了61% (OR:0.39,95%CI:0.27-0.59). 这种方法可以减少CRC的风险.
- 分层分析显示,中度和高坚持的女性和只有高坚持的男性的反向相关性.
结论:
- 坚持地中海饮食 (MD) 与降低结直肠癌 (CRC) 风险有关.
- 这种关联可能受到瘤位置,性别和年龄等因素的影响.
- 在地中海南部地区,MD可以作为一种有效的预防措施,防止CRC,尽管区域饮食的差异.
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