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作为一个多维生物标记物的TCF3:瘤性,基因组变化和免疫景观在泛癌分析中

Huiling Nie¹, Yang Yu¹, Siqi Zhou²

¹The Affiliated Eye Hospital and the Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210004, China.

Acta biochimica et biophysica Sinica

|August 29, 2024

概括

转录因子3 (TCF3) 影响癌症进展和瘤微环境. 这项研究揭示了TCF3作为一个关键的预后标志物和多种癌症的潜在治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症基因组学癌症基因组学

背景情况:

转录因子3 (TCF3) 与瘤发生有关,但其在瘤微环境 (TME) 和癌症表型中的作用尚未完全理解.
TCF3是TCF/LEF转录因子家族的关键成员.

研究的目的:

综合分析TCF3表达,DNA变异,预后意义以及与TME和免疫方面的关联.
研究TCF3在癌症进展中的功能作用,并确定潜在的治疗点.

主要方法:

来自多个数据集的17000多名患者的大规模泛癌分析.
用DNA变异分析,预后分析以及与TME和免疫学标志物的相关性.
在体外测试验证TCF3在癌症进展和分子途径中的作用.

主要成果:

TCF3/4/7在瘤与正常组织之间显示出不同表达的癌症,胆道癌症的变异率最高.
TCF3突变和变异影响患者的预后;TCF3表达强有力的预测生存,特别是免疫检查点抑制剂.
提升的TCF3与攻击性亚型,内异质性和血管生成相关,并通过NF-κB/MMP2通路在EMT,迁移,入侵和血管生成中的作用在体外验证.

结论:

在各种癌症中,TCF3与DNA变异,预后和TME显著相关.
TCF3作为一个有前途的分子标志物用于诊断和潜在的治疗点,特别是在皮膜黑色素瘤.

关键词:

这是一个TCF/LEF家族.在 TCF3 中,CF3 是表皮细胞-介质细胞过渡 (EMT)癌分析分析癌分析预后预后预后瘤微环境 (TME) 是指瘤的微环境.

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