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在自然冷解芽细胞转移周期中使用hCG用于质支持:一个队列研究
Wen Wen1, Na Li1, Juanzi Shi1
1Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
Frontiers in endocrinology
|August 29, 2024
概括
在自然冷解胚胎转移 (FET) 周期中,人类胆管激素 (hCG) 质期支持 (LPS) 与减少怀孕和活产率有关. 这种负面影响在自发排卵的女性中更为显著.
科学领域:
- 生殖医学 生殖医学
- 胚胎移植技术 胚胎移植技术
- 内分泌学 在内分泌学.
背景情况:
- 质期支持 (LPS) 常用于自然冷解胚胎移植 (FET) 周期,以改善生殖结果.
- 人体胆性腺激素 (hCG) 是常用于LPS的药物,作用于白体和子宫内膜.
研究的目的:
- 研究人类胆管性淋巴激素 (hCG) 在自然冷解胚胎移植 (FET) 周期中作为质期支持 (LPS) 的疗效.
- 评估基于hCG的LPS对临床怀孕,活产率和流产率的影响.
主要方法:
- 在2018年1月至2022年12月期间,4762名女性进行了自然FET周期的回顾性队列分析.
- 接受hCG LPS的组与没有接受hCG LPS的对照组之间的生殖结果的比较.
- 主要结局:临床妊娠和活产率. 二次结果:早期和总流产率.
主要成果:
- 与对照组相比,hCG LPS组的临床怀孕率 (63.82%与66.41%) 和活产率 (53.98%与57.15%) 显著降低.
- 两组之间早期或总流产率没有显著差异.
- 在有自发排卵的女性中,hCG LPS与临床怀孕和活产率相比显著降低.
结论:
- 人体胆性淋巴激素 (hCG) 质期支持 (LPS) 与自然冷解胚胎移植 (FET) 周期中的临床怀孕和活产率降低有关.
- 对于自发排卵的女性来说,hCG LPS的有害作用更为明显,这表明在这个子组中可能需要重新考虑其使用.
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