众包AOP开发:利用论文文献审查来识别知识差距,并促进研究翻译
Jacob I Reynolds1, Judy Choi2, Brian P Johnson1,3
1Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Current research in toxicology
|August 29, 2024
概括
负面结果途径 (AOP) 提供了评估化学毒性的框架,改善了风险评估. 开发和传播AOP加速了研究翻译,并增强了监管科学能力.
科学领域:
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
- 生物化学和生理学动力学
背景情况:
- 目前的化学风险评估主要依赖于体内研究.
- 新兴的毒理学工具显示出希望,但面临翻译挑战.
- 负面结果途径 (AOP) 维基提供了一个绘制化学效应的框架.
研究的目的:
- 描述一种以AOP为指导的文献审查过程,用于评估化学动力学.
- 为了突出AOP开发的翻译性监管相关性.
- 将AOP开发作为一种填补毒理学知识空白的方法.
主要方法:
- 进行了以AOP为指导的有针对性的文献审查.
- 批判性地评估生物途径的每个步骤,包括核心教条.
- 开发了AOP 460:平滑受体的对抗性导致 orofacial 裂作为一个案例研究.
主要成果:
- 在AOP指导的审查过程中,确定了数据缺口和翻译相关性.
- 对于监管和学术界来说,AOP的发展为监管和学术界带来了好处.
- 需要在经合组织框架下共同努力开发AOP.
结论:
- AOP的开发增强了化学风险评估和监管科学.
- 传播最新的AOP促进了研究翻译.
- 进一步开发AOP对于推进毒理学评估至关重要.
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