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在早熟的鸟类中,母性压力对几代人的影响

Marion Charrier^1,2,3, Sophie Lumineau¹, Isabelle George¹

¹Univ Rennes, CNRS, Normandie Univ, EthoS (Éthologie animale et humaine), UMR 6552, Rennes, France.

Royal Society open science

|August 29, 2024

概括

产前母亲的压力 (PMS) 影响子女的行为跨世代. 这项研究发现PMS对日本长行为的影响延伸到第三代,即使在F3大脑中没有表观遗传痕迹.

科学领域:

表观遗传学和行为科学
跨代遗传研究研究.
动物行为研究动物行为研究

背景情况:

已知产前孕产妇压力 (PMS) 会影响第一代 (F1) 后代的表型.
有证据表明PMS也可能影响后代,表明潜在的跨代影响.
之前在日本中进行的研究将F1的PMS与大脑质素修饰 (H3K27me3) 和卵子激素变化联系起来.

研究的目的:

调查PMS是否可以在第二代 (F2) 和第三代 (F3) 日本中引起持久的行为变化.
为了确定表观遗传标记和激素调节在PMS后的几代人之间存在的持久性.
分析对PMS行为反应的代际差异.

主要方法:

利用主要成分分析来评估F2和F3世代的行为概况.
在F3后代的大脑中检查了基因组翻译后修饰 (H3K27me3).
在F1和F2世代的卵子中分析了androstenedione的水平.

主要成果:

产前孕产妇压力 (PMS) 影响了F2和F3世代的行为特征,并存在世代差异.
在F2中观察到恐惧症增加,在雌性F3中增加恐惧和恐惧症.
在F3大脑中没有发现H3K27me3水平的显著变化;在F1和F2卵中,androstenedione水平显示出不一致的调制.

结论:

产前母亲压力 (PMS) 可以产生延伸到日本的第三代的表型效应.
由于PMS导致的行为变化可以在几代人中持续存在,即使在后几代人中没有检测到特定的表观遗传标记.
这些发现突显了压力反应的跨代遗传的复杂性质,具有潜在的性别特异性影响.

关键词:

日本的长.情绪反应性情绪反应性一代又一代,一代又一代的世代.产妇对母亲的影响.一个孩子的后代.产前压力在产前压力.

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