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系统性免疫炎症指数和骨关节炎之间的关系:来自NHANES 2005-2018年的横截面研究

Qiang He^1,2, Zhen Wang³, Jie Mei¹

¹Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in medicine

|August 29, 2024

概括

较高的全身炎症反应指数 (SIRI) 水平与成人骨关节炎 (OA) 风险增加有关. 关键SIRI值为4.757表示预测OA发展的重要门.

科学领域:

生物医学研究的研究.
炎症和免疫学炎症和免疫学
肌肉骨健康肌肉骨健康

背景情况:

骨关节炎 (OA) 是一种常见的退行性关节疾病,具有复杂的病因.
系统性炎症越来越多地被认为是OA病变发生的一个因素.
确定可靠的生物标志物来预测OA风险对于早期干预至关重要.

研究的目的:

调查系统性炎症反应指数 (SIRI) 与患骨关节炎 (OA) 的风险之间的关联.
探索SIRI作为成年人群中OA预测生物标志物的潜力.

主要方法:

从国家健康和营养检查调查 (NHANES) 数据库 (2005-2018) 中对11,381名参与者的横截面分析.
使用了加权的多变量回归模型和受限制的立方线模型.
分析包括分组调查和相互作用测试,以评估SIRI-OA关系.

主要成果:

在较高的log2 ((SIRI) 水平和增加的骨关节炎风险 (OR: 1.150,95% CI: 1.000-1.323,p < 0.05) 之间观察到具有统计学意义的正相关性.
确定了一种非线性关系,SIRI临界值为4.757. 超过这一值的SIRI水平与迅速增加的OA风险有关.
没有发现SIRI和其他影响OA风险的测试变量之间的显著相互作用.

结论:

系统性炎症反应指数 (SIRI) 是一种新的,临床上有价值的,方便的生物标志物,用于预测成人OA风险.
已识别的4.757的关键SIRI值为风险分层提供了实际的临床实用性.
这些发现支持系统性炎症在炎发病过程中的作用,并强调SIRI作为潜在的早期指标.

关键词:

尼汉斯 (NHANES) 是一个名人.一个横截面研究.骨关节炎是一种关节炎.关系关系关系关系关系关系关系.系统性免疫炎症指数

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