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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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页状状状细胞癌在食道的本位
A Priyadarshinee1, B Bhattacharya2
1KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal.
Kathmandu University medical journal (KUMJ)
|August 29, 2024
概括
页状状细胞癌 in-situ (SCCIS) 是一种罕见的食道疾病. 这一案例凸显了活检对于诊断细微的粘膜变化的重要性,即使内镜检查结果最小.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 状细胞癌 (SCC) 是最常见的食道恶性瘤.
- 页状SCCIS在食道中异常罕见,尽管在皮肤和生殖器官中描述.
- 对PPI耐药的消化不良引起了调查.
研究的目的:
- 在食道中报告一种罕见的页状SCCIS病例.
- 详细介绍临床,组织病理学和免疫组织化学发现.
- 强调诊断挑战和活检的重要性.
主要方法:
- 上部胃肠内镜与活检.
- 活检样本的组织病理学检查.
- 免疫组织化学分析 (p63,p53).
主要成果:
- 内镜检查显示只有轻度的红斑,没有明显的食道损伤.
- 活检显示全厚高度状发育不良与分散的非典型细胞.
- 免疫组织化学检测对p63和p53呈阳性,证实了页状SCCIS.
结论:
- 页状SCCIS呈现微妙,通常具有最小的内镜发现.
- 组织病理学和免疫组织化学对于诊断至关重要.
- 微微改变的粘膜的活检对于检测罕见的食道疾病至关重要.
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