睡眠呼吸障碍增加了糖尿病患者的死亡率
Teodora Vichova1,2, Marek Petras3, Petr Waldauf4
1Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
概括
糖尿病和睡眠呼吸障碍患者面临更高的死亡风险. 较低的平均氧和率预测死亡,而特定的呼吸障碍增加了治疗糖尿病患者的死亡率.
科学领域:
- 睡眠医学 睡眠医学
- 内分泌学 在内分泌学.
- 心血管疾病研究研究
背景情况:
- 睡眠呼吸障碍 (SDB) 和糖尿病 (DM) 经常同时存在.
- 关于SDB对糖尿病人群死亡率的影响的数据有限.
研究的目的:
- 调查SDB变量与DM患者死亡率之间的关联.
- 评估DM存在对SDB相关死亡结果的影响.
主要方法:
- 从睡眠心脏健康研究 (5,780名参与者,包括453名DM) 的数据分析.
- 在前性观测设计中利用了多睡眠和死亡率数据.
- 使用生存分析和比例危险回归模型来确定调整后的危险比率 (aHR).
主要成果:
- 在糖尿病患者中,较高的平均氧和率 (>91.4%) 与所有原因 (aHR 0.52) 和心血管死亡率 (aHR 0.44) 的降低相关.
- 严重的SDB (呼吸暂停-呼吸暂停指数>31或氧气不和指数>13.3) 在接受治疗的糖尿病患者中增加了全因死亡率 (两者的aHR为1.58).
- 睡眠效率和REM睡眠持续时间对糖尿病患者的死亡率没有影响,与非糖尿病患者不同.
结论:
- 中度至重度的SDB与治疗糖尿病患者全因死亡率的增加有关.
- 降低平均氧和是糖尿病患者全因和心血管死亡率的预测因素.
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