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Updated: Jun 14, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Published on: December 7, 2021

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在九个生物地理群体中药物遗传变异的模式

Sophia Hernandez1, Lucia A Hindorff1, Joannella Morales1

  • 1National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Clinical and translational science
|August 29, 2024
PubMed
概括

药物遗传 (PGx) 变体的频率在全球人口中显著不同. 大多数PGx数据低估了某些群体的代表性,这可能会扩大精准医学中的健康差异.

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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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