事件心力衰竭住院后认知衰退的轨迹:来自REGARDS研究的发现
Madeline R Sterling1, Joanna Bryan Ringel1, Monika M Safford1
1Division of General Internal Medicine Weill Cornell Medicine New York NY USA.
Journal of the American Heart Association
|August 29, 2024
概括
由于心力衰竭 (HF) 住院的成年人经历了更快的全球认知衰退. 在初次HF住院后,与没有HF的人相比,人们观察到认知功能的加速下降.
科学领域:
- 神经学和心血管医学.
- 认知健康与衰老问题
背景情况:
- 认知障碍在心力衰竭 (HF) 患者中很普遍,与不良结果有关.
- 第一次心力衰竭住院后认知衰退的具体轨迹仍未得到充分研究.
研究的目的:
- 为了研究第一次心力衰竭住院治疗的成年人认知衰退的速度.
- 为了比较发生HF医院住院的个体与没有发生HF住院的个体之间的认知衰退轨迹.
主要方法:
- 对23,894名年龄≥45岁的参与者进行了前性纵向研究 (REGARDS),最初没有HF.
- 专家评判心力衰竭住院情况.
- 使用六项选器评估全球认知功能;二次结果包括单词列表学习,单词列表延迟回忆和动物流利性测试,通过细分线性混合效应回归分析.
主要成果:
- 所有参与者在5年内都表现出认知能力下降,不论HF状态如何.
- 与无HF患者 (P<0.001) 相比,发生HF住院的个体在全球认知功能 (六项查得分) 中出现明显更快的下降 (P<0.001).
- 对于单词列表学习,延迟回忆或动物流利性测试分数在两组之间没有观察到下降率的显著差异;然而,HF与保存的射出小部分住院与更快的动物流利性测试下降有关.
结论:
- 发生心力衰竭的住院治疗与全球认知衰退的加快速度有关.
- 这种全球认知加速下降在其他测试的认知领域没有观察到.
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