患有多药耐药性HIV的人群的癌症
Tommaso Clemente1,2, Domenico Pontillo2, Vincenzo Malagnino3
1Vita-Salute San Raffaele University.
AIDS (London, England)
|August 29, 2024
概括
艾滋病毒和4类耐药性 (4DR) 患者在8年内面临12%的恶性瘤风险. 较高的病毒载量和男性性增加癌症风险,需要加强查和艾滋病毒管理.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 接受抗逆转录病毒治疗的人类免疫缺陷病毒 (HIV) 患者可能会产生耐药性.
- 四种类型的耐药性 (4DR) 是艾滋病毒管理的一个重大挑战,可能会影响长期的健康结果.
- 4DR与艾滋病毒感染者的恶性瘤风险之间的关联需要进一步调查.
研究的目的:
- 确定艾滋病毒和4DR感染者的长期恶性瘤概率和发病率.
- 为了确定与这种特定患者群体中癌症风险增加相关的风险因素.
- 为艾滋病毒感染者和4DR患者的癌症查和管理策略提供临床实践的信息.
主要方法:
- 追溯的队列分析.
- 纳入标准:艾滋病毒感染者,有记录的4类耐药性.
- 对癌症发病率和相关风险因素的分析,包括病毒载量和出生时分配的性别.
主要成果:
- 在4DR的第一个证据后,恶性瘤的8年概率为12%.
- 恶性瘤的发生率为每100个随访人年1.6人.
- 增加的癌前病毒载量 (调整后危险比率[aHR]=1.35每日志10副本/毫升) 和出生时分配的男性性别 (aHR=2.50) 与更高的癌症风险有关.
结论:
- 患有艾滋病毒和4DR的个体具有显著的恶性瘤发病风险.
- 实现长期病毒不可检测性,管理风险因素和实施向癌症查至关重要.
- 这凸显了在这个脆弱人群中需要积极和积极的癌症监测的需要.
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