乳腺癌中的表观遗传调节:治疗影响的新兴范式
Shilpi Sarkar1, Dheepika Venkatesh1, Thirukumaran Kandasamy1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, 781039 Guwahati, Assam, India.
Frontiers in bioscience (Landmark edition)
|August 29, 2024
概括
表观遗传修饰驱动乳腺癌的发病,进展和耐药性. 用新疗法准这些表观遗传变化为乳腺癌治疗提供了一个有希望的新途径.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 乳腺癌是妇女死亡的主要原因,其特点是异质性和对治疗方法的耐药性.
- 遗传和表观遗传改变是乳腺癌发病,进展,复发和转移的关键驱动因素.
- 表观遗传修饰,包括DNA甲基化和基因质突变,是癌症中基因表达的关键调节者.
研究的目的:
- 审查乳腺癌发病和进展中的异常表观遗传规则.
- 讨论与雌激素信号传递,表皮细胞转化为介质细胞转化 (EMT),癌症干性和耐药性相关的表观遗传修饰.
- 突出目前的表观遗传药物 (epi药物) 和用于乳腺癌治疗的组合疗法.
主要方法:
- 关于乳腺癌表观遗传机制的文献综述.
- 分析乳腺癌发展中的异常表观遗传调节.
- 调查当前的类药物及其治疗应用.
- 讨论组合治疗策略和未来的挑战.
主要成果:
- 异常的表观遗传修饰与乳腺癌的发病和进展密切相关.
- 特定的表观遗传变化与诸如雌激素信号传递,EMT,茎性和药物耐药性等关键途径有关.
- 包括DNA修饰剂和基因组修饰酶抑制剂在内的各种瘤药物正在研究乳腺癌治疗.
- 结合疗法,涉及性药物显示潜力,但需要进一步的研究.
结论:
- 表观遗传失调在乳腺癌的发病和治疗耐药性中起着至关重要的作用.
- 针对表观遗传修饰是新型乳腺癌治疗的有希望的策略.
- 进一步研究类药物和组合疗法对于克服治疗挑战和改善患者的治疗结果至关重要.
相关概念视频
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Genomic Imprinting and Inheritance
34.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.2K


