手术或放射治疗改善了早期非小细胞肺癌的老年患者的生存率:基于人口的分析
Pingfan Shi1, Ziye Li, Yanfei Zhang
1Integrated Medicine Department of Chinese and Western Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Journal of cancer research and therapeutics
|August 29, 2024
概括
对于早期非小细胞肺癌 (NSCLC) 的老年患者来说,手术和放射治疗都能改善生存率. 与放射治疗或不治疗相比,手术提供了特别显著的生存益处.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 胸部外科手术 胸部外科手术
背景情况:
- 对于患有早期非小细胞肺癌 (NSCLC) 的老年患者的最佳治疗方法仍在争论中.
- 在这个人群中,比较手术和放射治疗的证据有限.
研究的目的:
- 评估手术与放射治疗对老年人 (≥70岁) 和非常老年人 (≥80岁) 早期NSCLC患者的生存的影响.
- 为了比较治疗组和无治疗对照组之间的生存结果.
主要方法:
- 从SEER数据库 (1975-2018) 中对15,224名年龄≥70岁,诊断为早期NSCLC的患者进行了回顾性分析.
- 在手术,放射治疗和无治疗组中,总生存率 (OS) 和癌症特异性生存率 (CSS) 的比较.
主要成果:
- 与没有治疗 (74 vs. 7个月MST) 和放射治疗 (74 vs. 28个月MST) 相比,手术显著改善了OS.
- 与没有治疗相比,放射治疗也改善了OS (28 vs 7 个月MST).
- 对CSS观察到类似的生存益处,手术显示出最明显的效果.
结论:
- 手术和放射治疗都显著改善了老年和非常老年NSCLC早期患者的生存结果.
- 手术在这种患者群体中表现出特别显著的生存优势.
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