骨髓 talaromycosis 作为一个布基特淋巴瘤病例的初始表现
N E Hasbullah1, R Z A Raja Sabudin2, A S Asri1
1Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Department of Pathology, Kuala Lumpur, Malaysia.
The Malaysian journal of pathology
|August 29, 2024
概括
塔拉罗米塞斯马内菲是一种真菌感染,可以通过检查骨髓来诊断. 早期发现和治疗对于在免疫功能低下的患者中管理这种机会性感染至关重要.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 免疫功能受损的宿主感染
背景情况:
- 塔拉罗米塞斯马尔内菲 (Talaromyces marneffei) 是一种热二形真菌,会引起机会性感染.
- 诊断通常依赖于显微镜识别或从临床样本中分离真菌.
- 免疫功能低下的个体特别容易感染Talaromyces marneffei感染.
研究的目的:
- 报告一种与伯基特淋巴瘤同时发生的Talaromyces marneffei感染病例.
- 突出诊断挑战和及时干预的重要性.
主要方法:
- 一个23岁的男性患有发烧,咳和身体症状的病例报告.
- 临床检查显示出黄,皮肤炎,肝壮病和淋巴腺病.
- 诊断程序包括CT扫描,艾滋病毒查,骨髓吸血/活检和真菌培养.
- 进行肝脏活检以检查病变.
主要成果:
- 患者出现了暗示传播感染的症状.
- 骨髓检查证实了Talaromyces marneffei. 的存在.
- 艾滋病毒查是反应性的,表明免疫功能低下的状态.
- 肝脏活检显示了伯基特淋巴瘤和真菌体的同时存在.
- 尽管Amphotericin B治疗,但患者死于代谢酸和多器官衰竭.
结论:
- 骨髓的形态检查对于迅速诊断T. marneffei.的重要.
- 微生物培养可能耗时,延迟关键治疗.
- 及时诊断和积极管理对于改善T. marneffei感染的结果至关重要.
- 与诸如伯基特淋巴瘤等疾病的同时感染使管理复杂化.
更多相关视频
06:53Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
2.7K
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
6.8K
相关概念视频
01:31Pulmonary Tuberculosis III
316
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
316
01:28Pulmonary Tuberculosis II
215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215
01:22Bone Marrow Sampling and Transplants
316
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
316
01:29Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
01:26Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K