在结肠直肠癌患者中休息状态大脑功能变化
Yanan Xu1, Zihan Ma1, Jieyu Chen1
1The First Clinical Medical College, Gansu University of Traditional Chinese Medicine (Gansu Provincial Hospital), 730000 Lanzhou, Gansu, China.
结肠直肠癌患者表现出大脑功能的改变,特别是在认知领域. 这项休息状态fMRI研究确定了特定的大脑区域,如头和中后回转,显示活动减少,与认知能力下降有关.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 在瘤学瘤学.
背景情况:
- 大肠直肠癌 (CRC) 与认知障碍有关.
- 这种损伤的潜在神经成像机制尚不清楚.
研究的目的:
- 使用静止状态功能磁共振成像 (rs-fMRI) 调查CRC患者的改变大脑功能活动.
- 确定导致CRC认知障碍的神经成像机制.
主要方法:
- 在56名CRC患者和50名健康对照人群 (HCs) 上进行了rs-fMRI扫描.
- 用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 分析包括低频波动的幅度 (ALFF),中心度 (DC) 和区域均性 (ReHo).
主要成果:
- CRC患者在执行功能,视觉空间技能,记忆,语言和注意力方面得分较低.
- 在多个大脑区域观察到降低的ReHo,ALFF和DC,包括中枢后环,中尾环,舌环,角环,前环和中环.
- 异常的功能指标集中在中间的头环,中后环和语言环.
结论:
- 患有CRC的患者在静止状态下表现出异常的大脑功能,特别是在对认知至关重要的区域.
- 这项研究突出了潜在的生物学途径,有助于大脑损伤和神经认知衰退的CRC.
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