聚乙烯纳米塑料对人类肠道细胞的影响
Wassim El Basset1, Raphaël Cornu1, Taghrid Zaiter1
1Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France.
Nanotoxicology
|August 29, 2024
概括
性聚乙烯纳米塑料 (PE NPs) 对人类Caco-2细胞具有毒性,导致细胞毒性,氧化应激和基因毒性. 阴性PENP和HT29-MTX细胞上的PENP没有表现出这些有害影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 聚乙烯 (PE) 是一种无处不在的塑料;其降解产生有害的微塑料和纳米塑料 (NP).
- 与塑料颗粒暴露相关的健康风险需要进行毒理学评估.
研究的目的:
- 在人类Caco-2和HT29-MTX细胞系上研究无阴离子和阴离子表面活性剂PENP的毒性.
- 评估PENP对细胞毒性,氧化应激和基因毒性的影响.
主要方法:
- 关于PENP的物理化学特征.
- 对Caco-2和HT29-MTX细胞的急性和亚急性毒性概况的评估.
- 对细胞毒性,氧化应激和基因毒性的评估.
主要成果:
- 在培养基中,PE NPs的尺寸增加;在血清吸附后,zeta潜力变得独立于启动器电荷.
- 阴离子PENP在Caco-2细胞中诱导了时间和度依赖的细胞毒性,氧化应激和基因毒性.
- HT29-MTX细胞没有显示出毒性,可能是由于它们的保护性粘液层. 基因毒性与氧化应激相关,在48小时后0.1毫克/毫升.
结论:
- 发起者的负担显著影响PE NP的毒性.
- 阴离子PE NPs对肠道细胞构成健康风险,而阳离子PE NPs似乎更安全.
- HT29-MTX细胞的粘液层提供了对PE NP毒性的保护屏障.
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