阻塞性睡眠呼吸暂停在异常性正常压力脑症中的临床相关性
Simone Regalbuto1, Roberta Zangaglia1, Francesca Valentino1
1IRCCS Mondino Foundation, National Neurological Institute, Pavia, Italy.
European journal of neurology
|August 29, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在异常正常压力脑症 (iNPH) 中很常见,并且与较差的运动和认知功能有关. 这表明OSA可能会通过影响大脑流体动力学来恶化iNPH.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 异常性正常压力头症 (iNPH) 的发病因子尚不清楚.
- 阻塞性睡眠呼吸暂停 (OSA) 在iNPH患者中越来越多地被认可.
- 关于OSA在iNPH的临床影响的研究有限.
研究的目的:
- 调查iNPH患者中OSA的临床相关性.
- 评估iNPH中OSA和运动/认知缺陷之间的关联.
- 探索iNPH中OSA和脑脊液 (CSF) 生物标志物的关系.
主要方法:
- 38名iNPH患者的横截面观察研究.
- 评估包括临床秤,步态分析,神经心理测试和多睡眠学.
- 分析了脑脊液 (CSF) 神经退行生物标志物.
主要成果:
- 50%的iNPH患者患有OSA,其中63.2%患有中度至重度OSA.
- 在OSA+iNPH患者中,步态和认知表现较差.
- 患有OSA+iNPH的患者表现出CSF总tau和酸tau水平的升高.
结论:
- 在iNPH中,OSA非常普遍,并且往往是严重的.
- 在iNPH中,OSA与严重的运动和认知障碍有关.
- OSA可能会影响脑液动力学,导致iNPH的进展.
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