创伤后应激障碍增加了血栓形成风险:来自生物库数据集的证据
Hui Chong Lau1,2, Sinead M Sinnott3, Shady Abohashem1,2
1Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
American journal of hematology
|August 29, 2024
概括
创伤后应激障碍 (PTSD) 显著增加了深静脉血栓形成 (DVT) 的风险,特别是在女性中. 涉及压力活动和自主功能的神经免疫通路似乎调解了这种联系,这表明了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心血管医学 心血管医学
背景情况:
- 抑郁和焦虑与深静脉血栓症 (DVT) 有关.
- 创伤后应激障碍 (PTSD) 与静脉血栓栓塞的风险增加有关,特别是在女性中.
- 创伤后应激障碍-DVT关系的潜在机制尚未得到充分理解.
研究的目的:
- 为了调查PTSD和DVT风险之间的关联.
- 探索神经免疫机制是否调解PTSD-DVT联系.
- 为了确定这些关联是否在女性中更强.
主要方法:
- 一项大型队列研究 (N=106,427) 使用生物库数据,通过ICD-10代码定义PTSD和DVT.
- 一个子集 (N=1520) 接受了成像,以评估与压力相关的神经活动 (SNA).
- 测量了系统性炎症 (hs-CRP) 和自主活性 (HRV);进行了统计回归和调解分析.
主要成果:
- 创伤后应激障碍与DVT风险增加1.66倍相关 (p < .001),即使在对传统风险因素进行调整后也是如此.
- 在女性中,PTSD与DVT的关联是显著的,但在男性中却没有.
- 增加的SNA和减少的HRV调解了PTSD和DVT风险之间的关系.
结论:
- 患有PTSD的个体面临着DVT的风险增加,女性的风险更高.
- 与压力相关的神经活动和自主功能的改变部分解释了PTSD-DVT联系.
- 这些发现表明,在PTSD患者,特别是女性中,DVT的预防疗法可能是潜在的目标.
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