埃奎利祖马布作为肺移植后血栓性微血管病的救援治疗
Hernando Trujillo1, Ana Huerta2, Rodrigo Alonso3
1Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Clinical transplantation
|August 29, 2024
概括
肺移植后的血栓式微血管病变罕见但严重. 短周期的eculizumab在治疗严重病例方面表现出有效性,并观察到高响应率.
科学领域:
- 移植免疫学 移植免疫学
- 补充系统障碍 补充系统障碍
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血栓式微血管病变 (TMA) 是一个罕见的肺移植后并发症.
- 补充替代途径的过度激活与TMA有关,不包括初级非典型血清性尿素综合征 (aHUS).
研究的目的:
- 分析肺移植后TMA患者对eculizumab的治疗反应.
主要方法:
- 来自西班牙两个中心的11名TMA肺移植后患者的病例系列.
- 收集和分析了临床数据和对eculizumab的反应率.
主要成果:
- 大多数患者患有慢性阻塞性肺病 (COPD) 作为肺移植的主要适应症 (36%).
- 免疫抑制药物是最常见的TMA触发物 (73%).
- 在63.6%的病例中,eculizumab治疗导致了完全的TMA反应,在90.9%的病例中产生了血液学反应,28天后脏反应的中位数.
结论:
- 肺移植后的血栓式微血管病变很少发生,但可能很严重.
- 短期的eculizumab治疗在严重的TMA肺移植后治疗中似乎有效.
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