Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Radical Autoxidation01:20

Radical Autoxidation

2.1K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.1K
Mitochondrial Membranes01:45

Mitochondrial Membranes

9.3K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
9.3K
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

7.2K
During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
7.2K
The Supercomplexes in the Crista Membrane01:41

The Supercomplexes in the Crista Membrane

2.5K
The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
2.5K
Peroxisomes01:24

Peroxisomes

11.4K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
11.4K
Oxidation and Reduction of Organic Molecules01:19

Oxidation and Reduction of Organic Molecules

6.3K
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
6.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Surface tracking-assisted multi-cycle 4D MRI motion modeling for lung radiotherapy: a preliminary validation study.

Biomedical physics & engineering express·2026
Same author

Hairy Gels: Mimicking the Hair-Covered Architecture and Responses of Animal and Plant Tissues.

ACS applied materials & interfaces·2025
Same author

Mesoporous Silica Skin on Clay Nanotubes for Carbon Capture.

ACS applied nano materials·2025
Same author

Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations.

Frontiers in medicine·2025
Same author

Geometric characterization of an electromagnetic surface tracking system in a radiation therapy environment.

Journal of applied clinical medical physics·2025
Same author

Modulating the Aqueous Micellar Reorganization of Sequence-Defined Ionic Peptoid Block Copolymers by Ionizable Monomer Position and Solution pH.

Macromolecules·2025

相关实验视频

Updated: Jun 14, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

1.9K

由ROS,光和热驱动的气囊-小囊过渡.

Sai Nikhil Subraveti1, Morine G Nader1, Pedram AziziHariri2

  • 1Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA. sraghava@umd.edu.

Nanoscale
|August 29, 2024
PubMed
概括

研究人员从PDST和SDBS创建了对ROS敏感的囊泡,当暴露于活性氧物种 (ROS),光或热量时,它们会转化为囊,从而触发溶液释放.

更多相关视频

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.1K
Light-driven Enzymatic Decarboxylation
09:58

Light-driven Enzymatic Decarboxylation

Published on: May 22, 2016

10.7K

相关实验视频

Last Updated: Jun 14, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

1.9K
Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.1K
Light-driven Enzymatic Decarboxylation
09:58

Light-driven Enzymatic Decarboxylation

Published on: May 22, 2016

10.7K

科学领域:

  • 超分子化学 超分子化学
  • 纳米技术纳米技术
  • 材料科学 材料科学 材料科学

背景情况:

  • 囊泡是用于溶液封装的纳米容器.
  • 囊泡-小胞过渡 (VMTs) 是控制溶液释放的关键.
  • 反应性氧物种 (ROS) 与瘤微环境有关.

研究的目的:

  • 为了开发ROS响应的囊泡以触发溶解物释放.
  • 为了研究由ROS,光和温度诱导的VMTs.
  • 探索 catanionic 囊泡的组装和拆卸机制.

主要方法:

  • 使用 (4-phenylthiophenyl) diphenyl-sulfonium triflate (PDST) 和二甲硫酸盐 (SDBS) 制备卡塔尼尼克囊泡.
  • 使用像过氧化 (H2O2) 这样的活性氧物种 (ROS) 诱导VMTs.
  • 使用度,光散射和冷传输电子显微镜 (cryo-TEM) 进行VMT的表征.

主要成果:

  • 暴露于ROS会氧化PDST,诱导从囊泡到细胞的VMT.
  • 紫外线照射和高于临界温度的加热也引发了VMT.
  • 该研究通过多种分析技术提供了VMT的证据.

结论:

  • 由 PDST 和 SDBS 组成的 Catanionic 囊泡对 ROS,光和温度都有反应.
  • 这些对刺激有反应的囊泡提供了一个可扩展和具有成本效益的平台,用于触发溶解物释放.
  • 了解组装动态对于设计先进的药物输送系统至关重要.