由ROS,光和热驱动的气囊-小囊过渡
Sai Nikhil Subraveti1, Morine G Nader1, Pedram AziziHariri2
1Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA. sraghava@umd.edu.
Nanoscale
|August 29, 2024
概括
研究人员从PDST和SDBS创建了对ROS敏感的囊泡,当暴露于活性氧物种 (ROS),光或热量时,它们会转化为囊,从而触发溶液释放.
科学领域:
- 超分子化学 超分子化学
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 囊泡是用于溶液封装的纳米容器.
- 囊泡-小胞过渡 (VMTs) 是控制溶液释放的关键.
- 反应性氧物种 (ROS) 与瘤微环境有关.
研究的目的:
- 为了开发ROS响应的囊泡以触发溶解物释放.
- 为了研究由ROS,光和温度诱导的VMTs.
- 探索 catanionic 囊泡的组装和拆卸机制.
主要方法:
- 使用 (4-phenylthiophenyl) diphenyl-sulfonium triflate (PDST) 和二甲硫酸盐 (SDBS) 制备卡塔尼尼克囊泡.
- 使用像过氧化 (H2O2) 这样的活性氧物种 (ROS) 诱导VMTs.
- 使用度,光散射和冷传输电子显微镜 (cryo-TEM) 进行VMT的表征.
主要成果:
- 暴露于ROS会氧化PDST,诱导从囊泡到细胞的VMT.
- 紫外线照射和高于临界温度的加热也引发了VMT.
- 该研究通过多种分析技术提供了VMT的证据.
结论:
- 由 PDST 和 SDBS 组成的 Catanionic 囊泡对 ROS,光和温度都有反应.
- 这些对刺激有反应的囊泡提供了一个可扩展和具有成本效益的平台,用于触发溶解物释放.
- 了解组装动态对于设计先进的药物输送系统至关重要.
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