探索饮食,生活方式和肠道微生物组在结肠直肠癌发展中的关系:最近的更新
Biki Saha1, Rithi A T2, Subhamay Adhikary1
1Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India.
Nutrition and cancer
|August 29, 2024
概括
饮食和生活方式通过改变肠道微生物群,显著影响结肠直肠癌 (CRC) 风险. 了解这些肠道失生症的联系为CRC预防和治疗策略提供了新的途径.
科学领域:
- 胃肠道学和瘤学
- 微生物组研究 微生物组研究
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 仍然是全球癌症死亡的主要原因.
- 乳腺癌的患病率正在增加,特别是在年轻人群中.
- 仅仅遗传因素并不能解释CRC的发展;生活方式和饮食起着至关重要的作用.
研究的目的:
- 审查饮食和生活方式对肠道微生物群与结直肠癌有关的影响.
- 突出肠道失生症在CRC病变发生中的作用.
- 通过微生物组的改变来确定影响CRC风险的特定饮食和生活方式因素.
主要方法:
- 文献综述,重点关注最近的科学证据.
- 对连接饮食模式,生活方式选择和肠道微生物群组成的研究进行分析.
- 检查微生物代谢物和CRC发展之间的关系.
主要成果:
- 不健康的饮食 (高红色/加工肉类,低纤维) 和生活方式因素 (肥胖,不活动,吸烟,酒精) 与CRC风险增加有关.
- 这些因素诱导肠道失调,不平衡有利于有害微生物.
- 改变的肠道微生物群及其代谢物与CRC发病有关.
结论:
- 饮食和生活方式是肠道微生物组的关键调节者,显著影响结肠直肠癌风险.
- 准饮食和生活方式干预措施可能为CRC预防和管理提供有希望的策略.
- 进一步研究肠道微生物组在CRC中的作用对于开发新型治疗方法至关重要.
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