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认知分散及其在行为变异前性痴呆症和前性行为变异前性痴呆症中的功能相关性
Troy A Webber1, Steven P Woods2, Sara A Lorkiewicz1
1Mental Health Care Line, Michael E. DeBakey VA Medical Center.
患有行为变异前性痴呆症 (bvFTD) 个体在认知测试中表现变化更大,影响日常功能. 这项研究强调了个体内变异性作为检测bvFTD执行功能障碍的关键指标.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 老年学是一门学科.
背景情况:
- 执行功能障碍是行为变异前性痴呆症 (bvFTD) 的标志,这给诊断带来了挑战.
- 个人内表现变化 (IIV-d) 是执行功能障碍和功能衰退的潜在敏感标志物.
研究的目的:
- 评估基于分散的个人内变异性 (IIV-d) 的临床实用性和生态有效性,作为bvFTD执行功能障碍的衡量标准.
- 为了比较bvFTD/prodromal bvFTD,阿尔茨海默病 (AD) 和认知健康 (CH) 控制组的个体中的IIV-d.
主要方法:
- 一组477名参与者 (159CH,159AD,159bvFTD/prodromal bvFTD) 完成了统一数据集3.0神经心理学电池.
- 在12个神经心理测试中使用变异系数 (CoV) 测量了个体内变异性 (IIV-d),并与功能活动问卷对日常功能进行了相关联.
主要成果:
- 与CH组相比,bvFTD/prodromal bvFTD组显示出明显更高的原始和调整后的Cov (大效果大小).
- 人口调整后的Cov在bvFTD/prodromal bvFTD中低于AD (小效果大小).
- IIV-d指标准确地将bvFTD/prodromal bvFTD与CH区分开来,但不是从AD区分开来,并且与bvFTD/prodromal bvFTD组中更大的日常功能障碍有关.
结论:
- 患有bvFTD/prodromal bvFTD的人在神经心理评估中表现出更高的表现变化,影响日常生活.
- IIV-d证明了在bvFTD/prodromal bvFTD中识别执行功能障碍的临床实用性和生态有效性.
- 建议在不同的样本中进一步复制.
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