脑下垂体-垂体-上腺轴在父母患有重大情绪障碍的后代中发挥作用:一个元分析性综述
Lisa Serravalle1, Florencia Trespalacios1, Mark A Ellenbogen2
1Department of Psychology, Centre for Research in Human Development, Concordia University, 7141 Sherbrooke W., Montréal, QC, H4B 1R6, Canada.
European child & adolescent psychiatry
|August 29, 2024
概括
父母患有情感障碍 (OAD) 的后代表现出日间皮质醇水平升高,这是潜在的神经内分泌危险因素. 这一发现表明,较高的皮质醇可能会在有风险的年轻人中先发生情感障碍.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 父母患有情感障碍 (OAD) 的后代患有心理健康状况的风险较高.
- 患有情感障碍 (AD) 的个人表现出失调的下丘脑-垂体-上腺 (HPA) 轴活动.
- 在OAD中改变HPA轴的功能可能是AD发展的早期病因因素.
研究的目的:
- 量化综合现有的研究在OAD中昼间皮质醇模式.
- 调查影响OAD和白天皮质醇之间的关系的潜在调节者.
- 评估皮质醇水平升高是否成为发展ADS的风险因素.
主要方法:
- 一个系统的元分析,遵循PRISMA指南.
- 包括26项研究,包括3052名后代检查白天皮质醇.
- 统计分析使用强大的差异估计用于仅截取和元回归模型.
主要成果:
- 与对照组相比,OAD在各种每日时间点的平均皮质醇水平显著更高 (Hedge的g = 0.21).
- 在评估皮质醇唤醒反应 (CAR) 的研究中发现了出版偏差的证据,这表明对效应大小的潜在高估.
- 这些发现与先前的研究结果一致,这些研究表明在被诊断为ADs的年轻人中皮质醇升高.
结论:
- 父母患有情感障碍的后代的白天皮质醇水平升高可能成为神经内分泌风险因素.
- 皮质醇升高可能是高风险年轻人发展情感障碍的前兆.
- 限制包括皮质醇测量技术的变化和跨研究的AD评估.
相关概念视频
Hypothalamic-Pituitary Axis
59.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.7K
Physiological Foundation of Stress
52
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
52
Adrenal Gland Disorders
1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K
Stress and Mental Health
88
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
88
Human Genetics
549
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
549
Hormones of the Adrenal Glands
2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K


